Brain-derived Neurotrophic Factor: a Key Gene Risk Factor and Potential Therapy Target in Bipolar Disorder

Bipolar Disorder (BD) is a worldwide, multifactorial mental disorder characterized by manic and depressive symptoms of varying degrees. Among all the genetic risk factors correlated with BD, brain-derived neurotrophic factor (BDNF) has emerged as crucial neutropin that influences BD susceptibility strong conservative across species multiple downstream signaling pathways. However, mechanisms how BDNF polymorphism can contribute to are not yet lucid systematically reviewed. Val66Met variant capable inducing neurodegenisis Long-term Depression (LTD), both which account for pathogenesis in BD. The associated rapid cycling episodes Another variant, Arg125Met potential elicits neuronal apoptosis affecting maturation BDNF. In this paper, we briefly summarized epidemiology, symptoms, structure, its action function. We reviewed various detail provided insights into possible clinical treatment targets. been proven be noteworthy gene therapy targeted on promising therapeutic strategy requires further research.